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African-American women with high blood pressure may have high
levels of the amino acid homocysteine, according to a study in
the September issue of the American Journal of Hypertension.
People with
a high homocysteine levels have more risk of developing atherosclerosis
or hardening of the arteries, according to researchers at Thomas
Jefferson University in Philadelphia. Previous studies have linked
elevated homocysteine to a lack of folic acid, vitamin B-6 or
vitamin B-12 in the diet.
The study
involved 119 premenopausal African-American women and 56 African-American
men between the ages of 30 to 40 years. Of the 175 people in the
study, 31 women and 19 men had high blood pressure.
Although
average homocysteine levels were higher in both male and female study participants
with high blood pressure, the difference was only statistically significant in
women. Dietary information on the participants indicated that women with high
blood pressure had a lower intake of folic acid. The
researchers found no significant difference in average homocysteine levels between
male smokers and male nonsmokers. However, they found average homocysteine levels
to be significantly higher in female smokers than nonsmokers. The
researchers said their study supports the benefits of improving "dietary
intake of multiple nutrients along with smoking cessation as preventive measures
in this high-risk population."
"It is
important for physicians to be alert to the dietary and smoking
habits of their African-American female patients who could be
vulnerable to the deadly cascade of cardiovascular disease,"
added Dr. Michael Weber, an editor of the American Journal of
Hypertension.
Other
sources: American Journal of Hypertension: September 2003; 16:767-770
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